Mice sans synaptotagmin

Congenital CSF Rhinorrhoea sans Encephalocoele, sans Trauma, sans Tumour

The authors describe a case of cerebrospinal fluid rhinorrhea due to a congenital defect in cribriform plate, an anomaly that has not been described hitherto. It was successfully treated surgically.

'Sans teeth, sans eyes, sans taste, sans everything:' resourcing mental health services for older people.

Synaptotagmin II. A novel differentially distributed form of synaptotagmin.

Synaptotagmin is a synaptic vesicle membrane protein with properties suggestive of a role in synaptic vesicle exocytosis (Perin, M. S., Fried, V. A., Mignery, G. A., Jahn, R., and Südhof, T. C. (1990) Nature 345, 260-263). Here, we report the structure of a novel form of synaptotagmin named synaptotagmin II that is highly homologous to the originally described synaptotagmin, now referred to as ...

Synaptotagmin Function Illuminated

Neurotransmitter release occurs by exocytosis of synap-tic vesicles triggered by Ca 2 ϩ influx through voltage-gated Ca 2 ϩ channels. It was found many years ago that release shows a steep dependence on extracellular [Ca 2 ϩ ] and increases approximately with the fourth power of [Ca 2 ϩ ] (Dodge and Rahamimoff, 1967). It was proposed that Ca 2 ϩ entering through voltage-gated Ca 2 ϩ channels bi...

Information Elicitation Sans Verification

The recent advent of human computation — employing groups of non-experts to solve problems — has motivated study of a question in mechanism design: How do we elicit useful information when we are unable to verify reports? Existing methods, such as peer prediction and Bayesian truth serum, require assumptions either on the mechanism’s knowledge about the participants or on the information struct...